ABSTRACT
RNA interference (RNAi) is a phenomenon comprising the ability of double-stranded RNA (dsRNA) molecules to stimulate eukaryotic gene suppression in a sequence-specific manner. This entry first outlines the essential molecular biological principles of RNAi and then focuses on RNAi’s practical applications. The entry also explains how RNA can be delivered to or expressed inside mammalian cells, and what considerations are usually taken into account when choosing various RANi approaches.
