ABSTRACT
Skin is the largest organ of the human body, making it an attractive site for drug delivery. Transdermal drug delivery offers a noninvasive alternative delivery route for drugs that need to be administered by the parenteral route. However, the passive permeation of therapeutic molecules is limited by the compact structure of the stratum corneum, the uppermost layer of the skin. Several strategies have been developed to overcome the barrier properties of the stratum corneum, including chemical enhancers such as sonophoresis, microneedles, and iontophoresis. This entry is focused on the general principles, applications, and developments in iontophoresis.
