ABSTRACT
Breaching the skin’s stratum corneum barrier raises the possibility of administration of vaccines, gene vectors, antibodies, photosensitizers and even nanoparticles, all of which have at least their initial effect on populations of skin cells. Intradermal vaccine delivery, in particular, holds enormous potential for improved therapeutic outcomes for patients, particularly those in the developing world. Various microneedle-based vaccine delivery strategies have been employed, and they are discussed in this entry individually, and the importance of cutaneous immunobiology on the effect produced by microneedle-mediated intradermal vaccination is also reviewed.
