ABSTRACT
No issue in toxicology testing has provoked more controversy or protest than the Draize eye test. Published in the 1940s as a quantitative analysis of the effects of chemicals on rabbit eyes, it followed a similar manuscript by Friedenwald et al. (1944) that proposed a quantitative method for evaluating the severities of ocular testing methods. Today, advances in ocular toxicology are challenging the validity, precision, relevance, and need of the Draize eye test.
