ABSTRACT

In addition, much regulatory emphasis is placed on long-term human and animal exposures to environmental toxins, occupational exposure to hazardous substances, and chronic effects of food and dietary supplements. Consequently, there exists an important incentive for the scientifi c toxicology sector to develop test methods for predicting relative chronic hazards and risks of exposure to chemicals in daily life. As a result, simulation of these interactions requires the development of several types of studies in order to mimic the human situation.