ABSTRACT
Toxicokinetics refers to the events surrounding the metabolic fate of a compound administered in vivo or in vitro and how this metabolism affects the concentration of the compound in the target organ. Organs, tissues, and cells, therefore, are the objective of chemical distribution. Toxicokinetics therefore refers to numerous events that affect the absorption of a toxic dose of a chemical in the gastrointestinal tract, through the skin, via the lungs, or across the mucous membranes. To whatever extent absorption occurs, the chemical is modifi ed to a related compound, albeit more or less toxic. This metabolism occurs primarily in the liver, but also takes place in other metabolically active organs such as the lungs or kidneys.
