ABSTRACT

Instant Notes in Medicinal Chemistry provides concise coverage for undergraduates studying medicinal chemistry as part of a science, pharmacy or medical course. It is a truly multidisciplinary subject involving such subject specialities as organic chemistry, pharmacology, biochemistry, physiology, microbiology, toxicology, genetics and computer mod

section Section A|1 pages

The science of medicinal chemistry

chapter A1|2 pages

Introduction

chapter A2|2 pages

From Concept to Market

section Section B|1 pages

Drug targets

chapter B1|6 pages

Enzymes

chapter B2|10 pages

Receptors

chapter B3|3 pages

Carrier Proteins

chapter B4|2 pages

Structural Proteins

chapter B5|6 pages

Nucleic Acids

chapter B6|3 pages

Lipids

chapter B7|2 pages

Carbohydrates

section Section C|1 pages

Pharmacokinetics

chapter C1|1 pages

Pharmacokinetics

chapter C2|3 pages

Drug Absorption

chapter C3|3 pages

Drug Distribution

chapter C4|3 pages

Drug Metabolism

chapter C5|3 pages

Drug Excretion

chapter C6|4 pages

Drug Administration

chapter C7|3 pages

Drug Dosing

section Section D|1 pages

Biological testing and bioassays

chapter D1|1 pages

Testing Drugs

chapter D2|8 pages

Testing Drugs In Vitro

chapter D3|4 pages

Testing Drugs In Vivo

section Section E|1 pages

Drug discovery

chapter E1|2 pages

The Lead Compound

chapter E2|5 pages

Natural Sources of Lead Compounds

chapter E3|3 pages

Synthetic Sources of Lead Compounds

section Section F|1 pages

Synthesis

chapter F1|5 pages

Synthetic Considerations

chapter F2|10 pages

Stereochemistry

chapter F3|5 pages

Combinatorial Synthesis

section Section G|1 pages

Structure–activity relationships

chapter G2|3 pages

Binding Interactions

chapter G3|10 pages

Functional Groups as Binding Groups

chapter G4|5 pages

The Pharmacophore

section Section H|1 pages

Target orientated drug design

chapter H1|2 pages

Aims of Drug Design

chapter H2|5 pages

Computer Aided Drug Design

chapter H3|3 pages

Simplification Of Complex Molecules

chapter H4|4 pages

Conformational Restraint

chapter H5|5 pages

Extra Binding Interactions

chapter H6|7 pages

Enhancing Existing Binding Interactions

section Section I|1 pages

Pharmacokinetic orientated drug design

chapter I1|4 pages

Drug Solubility

chapter I2|5 pages

Drug Stability

section Section J|1 pages

Patenting and Manufacture

chapter J1|4 pages

Patenting and Chemical Development

chapter J2|6 pages

Optimization of Reactions

chapter J3|5 pages

Scale-Up Issues

chapter J4|4 pages

Process Development

chapter J5|5 pages

Specifications

section Section K|1 pages

Preclinical testing and clinical trials

chapter K1|2 pages

Toxicology

chapter K2|2 pages

Pharmacology and Pharmaceutical Chemistry

chapter K3|5 pages

Drug Metabolism Studies

chapter K4|4 pages

Clinical Trials

chapter K5|4 pages

Regulatory Affairs

section Section L|1 pages

Case study: inhibitors of EGF-receptor kinase

chapter L1|3 pages

Epidermal Growth Factor Receptor

chapter L2|2 pages

Testing Procedures

chapter L4|5 pages

Modeling Studies

chapter L5|2 pages

4-(Phenylamino)-Pyrrolopyrimidines

chapter L6|4 pages

Pyrazolopyrimidines

section Section M|1 pages

History of medicinal chemistry

chapter M1|1 pages

M1 The Age of Herbs, Potions and Magic

chapter M2|4 pages

The Nineteenth Century

chapter M3|3 pages

A Fledgling Science (1900-1930)

chapter M5|8 pages

The Antibiotic Age (1945-19705)

chapter M6|4 pages

The Age of Reason (1970s To Present)