ABSTRACT

Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

chapter 1|6 pages

General concepts in toxicology

chapter 2|17 pages

Role of Phase I metabolism in toxicity

chapter 3|19 pages

Role of Phase II metabolism in toxicity

chapter 4|18 pages

Co-ordinated responses to toxicity

chapter 5|24 pages

Toxicity case studies

chapter 6|11 pages

The real world - complex mixtures

chapter 7|20 pages

Role of genetics in toxic response

chapter 8|25 pages

Technologies for toxicity assessment