ABSTRACT
This chapter examines the analytic criteria in the context of occupational beryllium exposure as a case example. The discussion provides a basis for comparing the criteria of acceptance for disease susceptibility biomarkers used in clinical medicine and explains how they might be modified when considering use of a susceptibility biomarker in occupational disease prevention. The goals of this exercise are to explore the specific case of occupational beryllium disease and to provide an approach that can be generalized to other case studies. The chapter discusses the performed a quantitative analysis of the predictive value of the Glu-69 polymorphism for occupational beryllium disease. It examines the design and evaluation of alternative policies applied to a specific occupational disease, the analytic principles we present are generalizable. Problems can also occur when fire protection design engineers are required to work in domains outside their expertise.
