ABSTRACT
This base of knowledge on the α-helix and coiled-coil interactions provided a powerful starting point for initiating a more quantitative investigation of peptide self-organizing behavior. By using one helix as a template to direct the end-to-end condensation of two smaller helices, the first amplifying and cross-catalytic networks were generated and analyzed [39-41]. These approaches have now been extended to systems allowing for detailed network analyses of interacting peptides [42-44]. Even though these amplifying cross-seeding networks were limited to ligation events, they took a critical step toward designing self-organizing behaviors and built the tools for network analysis that should be applicable generally in other scaffolds [45].
