ABSTRACT
Chen Jiang, Xinguo Jiang, Yang Liu, Kun Shao, and Rongqin Huang
brain have been expected to be an effective strategy to deliver drugs across BBB into brain. Nanotechnology can be applied to develop technologies and approaches for delivering drugs across the BBB (Silva, 2007). Nanoscaled plat can be designed to carry out multiple specific functions potentially for successful drug delivery to the CNS. The use of nanoparticles (NPs) to deliver drugs to the brain across the BBB may provide significant advantages over current strategies (Lockman et al., 2002), and nanoscaled plat can be easily modified to render more functions. The modification provides several approaches for drug-loading NPs crossing the BBB such as adsorptive-mediated endocytosis (AME) (Tamai et al., 1997; Chen et al., 2004), cell-penetrating peptides-mediated transmembrane transport (Foged & Nielsen, 2008; Magzoub & Graslund, 2005), and receptor-mediated endocytosis (Lockman et al., 2002; Friden, 1994) as discussed in this section. Successfully constructed brain-targeting drug delivery systems that can be applied in the therapy for brain diseases such as Parkinson’s disease (PD), Alzheimer’s disease, and brain tumors will be also be discussed in this section. 12.2 Drug Delivery Systems to Brain
The success of drug delivery to brain depends on the effective carriers, and major drug transfer approaches employ liposomes, polymer, and so on. More suitable approaches to clinical application should be developed. Several kinds of drug carriers applied in brain drug delivery will be discussed in this section briefly.
