ABSTRACT
After the first work of Fritz and co-workers7 showing the potential of microcantilevers as a relevant label-free clinical diagnostic technique in the year 2000, many papers were published showing, as a proof of concept, the label-free detection of proteins and DNA and the ability to sequence DNA by hybridization.7-11Similarly, the cantilever array sensor can play a relevant role in the study of the tremendous complexity of the glycome. The identification and quantification of carbohydrate interactions with other biomolecules is important to understand the biological function of carbohydrates. To this end, Gruber and co-workers12described the development of cantilever array biosensors with a self-assembling carbohydrate-based sensing layer that selectively and sensitively detects carbohydrate−protein binding interactions.
