ABSTRACT
Drug testing on live human cells is an expensive, time-consuming,
and difficult process involvingmultiple specific assays with different
formats and dynamic ranges. It also requires highly trained
personnel to manipulate often dangerous chemicals for cell-labeling
purposes. Therefore this research addresses an effort to develop
an easy-to-use sensor device for label-free, real-time, live cell
monitoring. An investigation into an AlGaN/GaN transistor-based
sensor utilized for chemical and biological detection is presented.
The biocompatibility, sensitivity, and optimized operational design
are discussed in detail. Successful application of the sensor for
drug testing is demonstrated. Results presented here demonstrate
that an AlGaN-/GaN-based biosensor has potential to reveal the
rich signaling texture of living cells that can be beneficial for
development and testing of new drugs and treatment methods. This
study concludes that further research and development of all solid-
state sensor systems for biomedical applications is warranted.
