ABSTRACT
INTRODUCTIONMonitoring neurochemical and electrical changes is an important means of analyzing changes in brain neuronal activity evoked by high-frequency stimulation (HFS). Neurochemical changes include alterations in synaptic neurotransmitter release and possibly the release of adenosine from astrocytes. The standard experimental set-up for this type of analysis involves a hard-wired connection between the subject and an external monitoring device and computer, powered by line current. The wired connection between these devices and the subject makes it difficult to study brain function in awake, freely behaving animals [1, 2]. This fact as well as safety concerns has imposed limits on the potential for this type of research in human subjects.
