ABSTRACT
Immune alterations appear to play an important role in the etiopathogenesis of this disease, so immunosuppressants and immunomodulators have increasingly been investigated for the treatment of vitiligo. Calcineurin inhibitors are immunosuppressive drugs that were developed primarily for use in transplantation medicine. Although systemic calcineurin inhibitors have not been used in vitiligo, topical calcineurin inhibitors have shown promise in the treatment of vitiligo because of their immunomodulatory effects without the side effect profile of corticosteroids.
