ABSTRACT
A high carbohydrate diet leads to a metabolic syndrome (MetS) that poses an increased risk to cardiovascular function, although the effect of a high carbohydrate diet on systemic metabolism has not yet been discovered. However, it has been mentioned that an abnormal fatty acid metabolism plays an intimate role in the pathogenesis of MetS related cardiovascular diseases. Metabolic syndrome is characterized by a combination of obesity, hypertension, insulin resistance, dyslipidemia and impaired glucose tolerance. This multifaceted syndrome is often accompanied by increased blood pressure, decreased cardiac output and metabolic tissue damage in the heart. The primary endpoints of cardio-metabolic risk are coronary and peripheral arterial disease, myocardial infarction, congestive heart failure, arrhythmia and stroke. Alterations in expression and/or functioning of several key proteins involved in regulating and maintaining ionic homeostasis can cause cardiac disturbances.
