ABSTRACT
The animal toxicology of the various natural and synthetic tocopherols is probably similar, and all display only very low toxicity. From the high concentration found in their livers, it seems likely that animals such as the polar bear and seal tolerate very large daily doses without clinical effects. Clinical and physiological manifestations of vitamin D toxicity in laboratory animals, especially the rat, dog, or rabbit, are similar to those in humans overdosed with this vitamin. The animal toxicology of the various natural and synthetic tocopherols is probably similar, and all display only very low toxicity. Several naturally occurring tocopherols possess varying degrees of vitamin E activity. In experimental animals the prevention or curing the fatty infiltration of the liver can be demonstrated with high doses of choline. Inositol is a compound of relatively low toxicity and its effects on animals and humans has been recently reviewed by Tomita.
