ABSTRACT
The interaction between protein and lipid is a fundamental process of biological systems that has received increasing attention. Among biological systems in which protein-lipid interactions are considered to be of importance, one can include certain enzyme and receptor systems, serum lipoproteins, blood coagulation processes, lung surfactant, and many processes involving cell membranes. There are many aspects of protein-lipid interactions in biological membranes, from theoretical treatments of the interaction forces involved to studies on model and reconstituted systems using components purified from membranes, studies of the influence of proteins on membrane fluidity, or on the lipid requirement of enzymes. Many of the studies of protein-lipid interactions in monolayers are difficult to interpret because of the inadequate techniques used and because the proteins and/or phospholipids employed were often impure. The effects of soluble proteins on permeability of lipid vesicles have been studied with the aim to establish a functional aspect of protein-lipid interactions.
