ABSTRACT
The theory describing the magnetic interaction of superparamagnetic compounds with water protons has been described by different theoretical models derived from the classical outer-sphere paramagnetic relaxation model. Consequently, a full set of analytical methods should be used to characterize the efficacy, purity of nanoparticles, and reproducibility of the synthesis process. The distribution and elimination data obtained with C-ferumoxtran-10 are investigated, in comparison with Fe data, to understand the metabolism of nanoparticles. The introduction of superparamagnetic nanoparticle contrast agents in magnetic resonance imaging has constituted a major improvement of the range of tools available to clinicians. Bulk ferromagnetic materials are composed of fully magnetized domains of micron size. In the absence of an external magnetic field, a ferromagnetic material is not magnetized, as the magnetization of these ferromagnetic domains is oriented in directions. The synthesis of superparamagnetic nanoparticles is a complex process because of their colloidal nature.
