ABSTRACT
A major consideration in tissue engineering is the pursuit of scaffolds that provide an architecture on which seeded cells are directed to proliferate and differentiate to form new tissues and organs. Such tissue-engineered constructs composed of scaffolds preseeded with cells are one of the most promising approaches to generate functional replacement tissues. Such strategies are dictated by the primary purpose of the implant and the availability of a suitable cell source. These tissue engineering approaches allow the production of new extracellular matrix (ECM) resembling that of the native tissue to replace or regenerate the injured tissues or organs. Using this concept, various preclinical and clinical studies in different tissue systems have been
CONTENTS
4.1 Introduction .................................................................................................. 79 4.2 Strategy: In Situ Tissue Regeneration ....................................................... 81
4.2.1 Tissue-Specic Stem/Progenitor Cells ......................................... 81 4.2.2 Host Cell Mobilization .................................................................... 82
4.3 Design Considerations of Smart Biomaterial Scaffolds..........................83 4.3.1 Bioactive Molecules .........................................................................83 4.3.2 Biomaterial Scaffolds .......................................................................85
