ABSTRACT
The emerging field of pharmacogenetics has the potential to advance the science of nicotine dependence treatment by generating new knowledge about genetic factors that influence therapeutic response. The basic premise of this approach is that inherited differences in drug metabolism and drug targets have important effects on treatment toxicity and efficacy. This chapter reviews evidence supporting the potential utility of a pharmacogenetic approach to the treatment of nicotine dependence. Future research directions and issues related to the clinical integration of genetic testing to tailor nicotine dependence treatment are also addressed.
