ABSTRACT
This chapter will attempt to summarize the application of chiral auxiliaries at a scale important to the chiral fine chemical business. In addition, and as important, there are numerous cases where a chiral auxiliary has been used in the early stages of pharmaceutical development and the potential exists for this approach to be used in future work at larger scale. Last, there exists a limited number of cases where the auxiliary exists as part of an active drug. The known industrial applications, the potential applications, and the presence of auxiliaries in active drugs will all be addressed.
