ABSTRACT
I. Introduction ...................................................................................................................... 451
II. General Kinetic Models for Acid-Base Reactions in Solutions .................................... 452
A. The Two-State Proton-Transfer Reaction Model
(The Eigen-Weller Model) ..................................................................................... 452
B. Free-Energy Correlations of the Proton (Deuteron) Transfer Rates....................... 454
C. The Isotope Effect in a Series of Similar Reactions ............................................... 455
III. The Isotope Effect in the Equilibrium Constant of Photoacids ...................................... 456
IV. The KIE in Photoacid Dissociation ................................................................................. 459
V. Concluding Remarks on the KIE in Photoacid (Phenol-Type) Dissociation ................. 462
References..................................................................................................................................... 462
The effect of isotope substitution (H/D) on the kinetics of acid-base reactions has long been
a primary mechanistic tool in proton-transfer research.
