ABSTRACT
The isolated kidney is appropriate for the study of several physiological and biochemical aspects of the renal function. The main advantage is that it is possible to work under conditions in which the variables can be modied in a controlled way, eliminating the systemic inuences, while the anatomic, biochemical, and functional characteristics are preserved.1 Therefore, this model allows the study of the direct effects of different substances on the kidney in the absence of extrarenal factors that interfere in the information obtained in experiments carried out in vivo.
