ABSTRACT
The experimental model of myocardial infarction developed in rats is the most widely used throughout the world. This model closely reproduces many aspects of ischemic cardiomyopathy and heart failure, having several advantages compared with similar models performed in other species. The surgical procedure for developing myocardial infarction in the rat, as well as its uses, limitations, advantages, and disadvantages, will be described in this chapter. Surgical material is also described, plus there are tips to improve the results of the surgery. It is important to note that this surgical procedure represents a model of permanent coronary artery ligation that leads to myocardial infarction.
