This chapter explores different approaches to creating knowledge. Research aims to add to knowledge by applying various strategies and methods, but these entail assumptions about what is being investigated and how it can be known. Can we attempt to understand everything by using the same methods of inquiry, or must different kinds of reality be approached in different ways? Is there only one ‘way of knowing’ or are there several alternative ways? Can any of them guarantee certain knowledge or absolute truth? Is science such a way and, if so, what is science?