ABSTRACT
Current computational issues in genome research have not only arisen from the recent accumulation of genome data but have also been built up from past experience of computer-assisted sequence analysis. Within the last three decades, molecular biology and genetics have increasingly relied on the use of computers for data analysis. At the same time the nature and scope of problems to be solved with the help of computers have evolved because technological advances have gradually modified details of laboratory work. Thus the nature and quality of generated data have changed, as have the nature and quality of inference from these data.
