ABSTRACT
I. INTRODUCTION Central diabetes insipidus (CDI), also called neurogenic, hypothalamic, or cranial diabetes insipidus, is caused by a failure of secretion and/or release of antidiuretic hormone, or vasopressin, by supraoptic and paraventricular nuclei, in which it is synthesized, or from the posterior pituitary, in which it is stored. This failure induces in affected patients a lowest gravity polyuria with polydipsia, which prevents an increase in plasma osmolality.
