ABSTRACT
Drug transporters have been a rapidly emerging area in biomedical research for the last 10 years. These drug transporters are proteins located in the intracellular and plasma membranes making up to 2-3% of body total proteins. Drug resistance, low bioavailability, high intersubject variability and gender difference in drug disposition have been linked to drug transporters [1-3]. When a drug is introduced into the body, the transport of a drug from the administered site such as the intestine (absorption) to the target organs such as brain (distribution) and to the organ for metabolism and excretion in the liver and kidney (disposition and elimination) is an important process, in which drug transporters play a critical role. Since this a very broad field, this chapter will discuss the transporters important in ADME (absorption, distribution, metabolism and excretion) of drugs.
