ABSTRACT
CSF p-tau 199 levels in the AD group were significantly elevated (p < 0.001) compared to those in all the other non-AD groups, including patients with acute neurological conditions such as meningoencephalitis and Creutzfeldt-Jakob disease (CJD) (Figure 23.1). On the other hand, CSF t-tau levels were occasionally very high in the meningoencephalitis and CJD groups,
AD FTD CBD PSP DLBD VD ME CJD NC ND
C SF
p -t
au 1
99 (f
m ol
/m l)
Figure 23.1 The results of cerebrospinal fluid (CSF) phosphorylated tau at serine 199 (p-tau 199) levels, among groups with Alzheimer’s disease (AD), frontotemporal dementia (FTD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), dementia with Lewy body disease (DLBD), vascular dementia (VD), meningoencephalitis (ME), Creutzfeldt-Jakob disease (CJD), normal controls (NC) and neurological disease controls (ND)
although most CSF t-tau levels were significantly increased in the AD group compared to normal control groups (Figure 23.2).
