ABSTRACT
The blood-brain barrier (BBB) forms the interface between the central nervous system (CNS) and the peripheral circulation. It is capable of virtually excluding from the CNS many substances and controls the entry of most others and so is responsible for the nutritive and homeostatic environment of the CNS.1 In addition, the BBB is increasingly recognized to play a role in communication between the CNS and peripheral tissues through its ability to control the exchange of regulatory and informational molecules such as peptides and proteins.2
