ABSTRACT

It has been reported that sperm DNA damage is predictive of fertilization and pregnancy after natural conception1-3 and following the use of different techniques of assisted reproduction, namely intrauterine insemination (IUI)4, in vitro fertilization (IVF)5-8 and intracytoplasmic sperm injection (ICSI)9-12. This has important clinical implications for assisted reproduction techniques (ART), because the more invasive is the technique, the higher is the risk that a genetically damaged male genome will be transferred into the oocyte and fertilize the oocyte in vitro10,13.