ABSTRACT
The first documented application of artificial insemination was presented in London in the 1770s by John Hunter. A cloth merchant with severe hypospadias was advised to collect semen in a warmed syringe and inject the sample into the vagina. Sims reported his findings of postcoital tests and 55 inseminations in 1873. Only one pregnancy occurred, but this could be explained by the fact that he believed that ovulation occurred during menstruation.
