ABSTRACT

The diagnosis of endometritis is a pathological diagnosis based on histology at this time. Among young women who undergo endometrial biopsy, histological endometritis is found more often in those biopsied during the proliferative rather than the lateral phase of the menstrual cycle,10,14 suggesting a uterine response to an increased exposure of microbes or other molecules at menses. A less likely but possible explanation is an effect of the proliferative phase milieu to reduce the endometrial inflammation response. The histological definition of endometritis includes the presence of both plasma cells in the endometrial stroma and of PMN in the superficial layers of endometrial tissue.2

Findings used for the clinical diagnosis of endometritis are non-specific and subtle, as mentioned. Clinical findings present in women with endometritis include mild abdominal pain and mild cervical and uterine tenderness. Other non-specific tests include an increased number of vaginal inflammatory cells.30,31 These findings are also present in women with cervicitis only without endometritis and in women with salpingitis (where endometritis is usually present).14 More specific molecular testing of cervical fluid for endometrial inflammation has not yet been developed. This leads