ABSTRACT
Preeclampsia and intrauterine growth restriction (IUGR) represent the most commonly encountered placental disorders in clinical practice; they may occur in isolation or coexist. Preeclampsia is a multisystem disorder, in which hypertension and endothelial dysfunction lead to
end-organ malfunction. IUGR results from insufficient transfer of nutrients and oxygen to the developing fetus. Both preeclampsia and IUGR originate from dysfunction of the uteroplacental interface. While these conditions normally present in the latter half of pregnancy, current understanding of these complex conditions proposes that changes occurring early in pregnancy,
from implantation onwards, are important in the development of both preeclampsia and IUGR.
