ABSTRACT
Leukemias are malignant hematopoietic disorders characterized by increased proliferation, extended survival, and/ or disruption of differentiation of hematopoietic progenitors that result in clonal expansion of leukemic cells in the bone marrow, blood, or other tissues. The most common types of leukemia are acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), and chronic lymphocytic leukemia (CLL), which differ with regard to the incidence, clinical presentation, disease course, and prognosis, as well as the underlying biology and cytogenetic and molecular genetic alterations (1-4).
