ABSTRACT

Alzheimer’s disease (AD) is a gradually progressive degenerative disease often characterized by an early memory impairment followed by loss of other cognitive functions and personality. The precise temporal onset of the disorder is difficult to discern, but some estimates indicate the process may have started many years prior to the actual clinical diagnosis.1 The degenerative process begins in the medial temporal lobe and spreads through the limbic system and ultimately to the neocortex.2 This progression of pathology is likely to parallel the appearance of clinical symptoms. Typically, a memory impairment is the first symptom reflecting the onset of the degenerative process.3