ABSTRACT
They present in the typical fashion for soft tissue sarcoma, either in the extremity (Figure 7.22) or in the retroperitoneum (Figure 7.23). The diagnosis is based on biopsy and the typical findings of the pathologist. It is important to separate out leiomyosarcomas that are cutaneous and superficial from those that are deeper. They behave in a very different biological fashion. The superficial ones are frequently much more benign in their behavior. Conversely, as mentioned, the deeper leiomyosarcomas are frequently aggressive and refractory to many forms of treatment.38
