ABSTRACT
In a study of 911 patients with extremity soft tissue sarcoma from MSKCC, factors predictive of local recurrence, metastasis and survival were analyzed.4 Independent predictive risk factors for local recurrence were age >60 years, upper extremity, leiomyosarcoma subtype, and positive microscopic margins. By multivariate analysis, positive microscopic margins were the significant factor for the development of local recurrence (Table 12.1). Patients with high-grade or deep location extremity lesions were more likely to develop systemic disease. The lung was the site of metastasis in 38 patients who developed systemic disease.
