ABSTRACT

Prognosis for both spontaneous intracerebral hemorrhage (ICH) [1-4] and aneurysmal subarachnoid hemorrhage (SAH) [4-7], despite improvements in medical and neurosurgical treatment, has largely remained unaffected. Outcome of both these main hemorrhagic stroke subtypes, which together account for approximately 20% of all strokes, is still determined mainly by the severity of bleeding, and overall case-fatality still reaches 40-50% [2,3,7]. Hence, identification of modifiable risk factors for ICH and SAH as well as for impaired outcome after these strokes has been important in order to influence the incidence and outcome of these stroke subtypes as well as to understand better the pathogenesis of these hemorrhages.