ABSTRACT
Marijuana alters brain physiology by activating specific cannabinoid receptors (CB1) to modulate neuronal activity. Electrophysiological data obtained with extracellular and intracellular recording techniques indicate that activation of CB1 influences several neuronal properties. However, full (synthetic) and partial (natural) CB1 ligands appear to differentially affect some aspects of neurotransmission, a feature to consider when interpreting cannabinoid actions.
