ABSTRACT
After taking a kwao keur preparation daily for one month, Wanandorn (1933) described a swelling and soreness of the breasts which gradually disappeared when the medicine was discontinued. Sukhavachana (1941) gave an alcoholic extract of kwao keur in syrup to two patients and noted various oestrogen-related changes (e.g. an increase in the size of the uterus) but no ill-effects. In contrast, trials by Schoeller et al. (1940), using a crystalline compound probably identical with miroestrol, were abandoned when three women patients developed severe nausea after taking a 1 mg dose. Earlier tests on rats, rabbits, cats and monkeys had shown no adverse side effects even at very high dose levels (Schoeller et al., 1940).
