ABSTRACT
The New Zealand Obese (NZO) mouse is a model of Type 2 diabetes that displays the appropriate characteristics of obesity, impaired glucose-stimulated insulin secretion and insulin resistance in muscle, fat and liver (Proietto and Larkins, 1993). Unlike other animal models of Type 2 diabetes, such as the ob/ob, db/db, Ay mice and the falfa (Zucker) rat which have single-point genetic mutations, the syndrome in the NZO mouse is likely to be the result of defects in multiple genes. In this regard, the NZO mouse is a good model of human Type 2 diabetes.
