ABSTRACT
The Nagoya-Shibata-Yasuda (NSY) mouse strain was established in 1980 as an inbred polygenic animal model with spontaneous development of Type 2 (non-insulin-dependent) diabetes mellitus, by selective breeding for glucose intolerance from outbred Jcl: ICR (Shibata et al., 1980). The NSY mouse closely mimics human Type 2 diabetes in that the onset is age-dependent, the animals are not severely obese, and
both insulin resistance and impaired insulin response to glucose contribute to disease development (Ueda et al., 1995). We summarize the pathogenesis and genetic features of Type 2 diabetes in this model.
