ABSTRACT

Hans-Jacob Bangstad and Susanne Rudberg Department of Paediatrics, Aker and Ullevål Diabetes Research Centre, Ullevål University Hospital, Oslo, Norway, and The Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden

Associations between early stages of diabetic nephropathy and structural changes is far from clarified since some reports present rather marked changes in patients in the preclinical stage whereas others found very moderate changes in the early stage of nephropathy. Hence the issue is still a challenge to further studies. This chapter concentrates on the renal morphological changes in patients with Type 1 diabetes and early nephropathy and the possibilities of influencing the progression by blood glucose control and antihypertensive treatment.