In the Hebrew Bible, there is a story about a remarkable man to whom Abraham pays his tithe. His name is Melchizedek. Unlike most other people whose genealogy is known and recited, Melchizedek has no clan, no genealogy, no birthdate and no fixed address. As a priest, he is a figure who, in a sense, resides outside time and space. To Hindu eyes, he represents the eternal hidden within the temporal. In this essay, I would like to discuss the relationship between the scientific and spiritual quests from a Melchizedekian perspective or, as the Apostle Paul said to the sophisticated Athenians with their many gods, “I want to talk to you about the unknown God.” I will focus more on the spiritual aspect of the Hindu perspective and not at all on its institutional history because my tradition represents not so much a particular religion as it does the human spirit; and “Hindu” is used here as the old Greeks and Persians used it to denote the way of life of the people of a geographic location.