ABSTRACT
Glaucomatous optic neuropathy (GON) has been known clinically for more than 150 years as optic nerve head excavation.We are, however, only beginning to understand the corresponding changes at the cellular and molecular levels. More information can be expected in the next few years from studies using immunohistochemistry and in situ hybridization.The main problems are the difficulty of obtaining fresh human material and the lack of good animal models, especially for normal-tension glaucoma.
