HIV infection can lead to a wide range of mental health problems in individuals living with the infection, and in their partners, relatives and carers, as reviewed in previous chapters. Apart from the treatment of HIV and its complications by means of medical treatments, a variety of mental health interventions can be used to prevent or minimize mental health problems. Such interventions may include the use of medication with effects on mood or behaviour (Chapter 9), and the use of psychological approaches, from counselling to different forms of psychotherapy. Psychological and psychopharmacological interventions are not mutually exclusive, and they can usefully be given at the same time (Markowitz et al., 1998). This chapter reviews the main forms of psychological intervention appropriate for people with HIV.