ABSTRACT
The basis for gene therapy is to change the expression of some genes in an attempt to treat, cure, and ultimately prevent disease. One of the principal barriers to effective gene therapy is the development of efficient vectors that can deliver the therapeutic gene to its target site, the nucleus. Viral vectors have evolved into the most efficient vectors for introducing foreign genes into cells. However, safety concerns and the immunological profile of viral vectors have steered research toward the development of efficient nonviral systems.1
