ABSTRACT
The chief difference is the material that is being incorporated into the liposomes, and this itself can have a tremendous influence on the properties of liposomes, for which allowances and adjustments have to be made. Breaking things down to their simplest form, the two properties of liposomes that one wants to control are membrane stability and vesicle size, because these are the overriding factors that govern longevity in vitro and interactions in biological or other systems. Although there is a tremendous choice in the methods of preparation, the lipids incorporated, and the conditions employed, in most cases, the liposomes one ends up using are identical in the majority of their characteristics and composition to those employed by everyone else. Ionic amphiphiles that form vesicles tend to possess hydrophilic headgroups that are much more compact.
